Spot-on uses a unique blend of natural ingredients (clove leaf oil, thyme white oil, and cinnamon oil) with absolutely no pyrethrins, permethrins, or cedar oil, so it's safe for your dog and the entire family. Includes 3 -8 applications with a universal applicator that easily applies between the shoulder blades on both small breed dogs and large breed dogs (see directions for proper application). Safe for use on dogs 12 weeks or older. Dog wipes (6 in x 8 in) allow for a targeted, easy application Carefully formulated natural ingredient blend of peppermint oil and clove extract; absolutely no pyrethrins, permethrins, or cedar oil Flea and tick wipes are perfect for dogs and cats 12 weeks or older Non-staining formula that is great for home surfaces like countertops and flooring Wipes also repel mosquitoes